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Therapeutic potential of purine analogue combinations in the treatment of lymphoid malignancies
Author(s) -
Johnson S. A.,
Thomas W.
Publication year - 2000
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/1099-1069(200012)18:4<141::aid-hon666>3.0.co;2-#
Subject(s) - purine analogue , purine , cancer research , medicine , oncology , biology , biochemistry , enzyme
The main purine analogues with activity against lymphoid malignancies are fludarabine, cladribine and pentostatin, all of which are active against slowly proliferating cells through their inhibition of DNA repair and therefore have significant synergistic activity with cytotoxic agents which cause DNA damage. Combinations of purine analogues and alkylating agents or platinum compounds result in markedly increased activity but at the expense of more severe haematological toxicity, while evidence of synergy with anthracyclines/anthracenediones is apparent in the treatment of malignant lymphoma. Interaction between fludarabine or cladribine with deoxycytidine kinase results in a significant enhancement of the activity of cytarabine. Unexpected evidence of clinical synergy is also apparent in combinations of purine analogues and anti‐CD20 monoclonal antibodies. Copyright © 2000 John Wiley & Sons, Ltd.