Premium
DNA repair mechanisms and acute myeloblastic leukemia
Author(s) -
DasGupta E. P.,
Seedhouse C. H.,
Russell N. H.
Publication year - 2000
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/1099-1069(200009)18:3<99::aid-hon662>3.0.co;2-z
Subject(s) - dna repair , acute myeloblastic leukemia , leukemia , dna , dna damage , computational biology , biology , medicine , cancer research , genetics
DNA repair mechanisms play a vital role in maintaining genomic integrity. With the wealth of knowledge gained recently on these processes it is becoming clear that defects in repair proteins and proteins associated with the regulation of repair are connected to many different human diseases including cancer. This paper has aimed to review the four major DNA repair processes and in particular concentrate on their association with acute myeloblastic leukemia (AML). Copyright © 2000 John Wiley & Sons, Ltd.