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Economic evaluation alongside n ‐of‐1 trials: getting closer to the margin
Author(s) -
Kar Jonathan,
Qizilbash Nawab
Publication year - 2001
Publication title -
health economics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 109
eISSN - 1099-1050
pISSN - 1057-9230
DOI - 10.1002/1099-1050(200101)10:1<79::aid-hec567>3.0.co;2-z
Subject(s) - margin (machine learning) , randomized controlled trial , clinical trial , estimation , economic evaluation , medicine , intensive care medicine , economics , computer science , surgery , machine learning , management , pathology
The n ‐of‐1 trial is a particularly flexible form of randomized controlled trial that involves a single patient receiving multiple episodes of alternative therapies. Although n ‐of‐1 trials are only applicable in certain treatment areas, the collection of economic data within such trials may provide unique advantages. This paper illustrates the issues around the use of economic n ‐of‐1 trials with a hypothetical example, and discusses their potential for the estimation of individualized cost‐effectiveness. Copyright © 2001 John Wiley & Sons, Ltd.