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The impact of chirality of the fluorinated volatile inhalation anaesthetics on their clinical applications
Author(s) -
AboulEnein Hassan Y.,
Bojarski Jacek,
SzymuraOleksiak Joanna
Publication year - 2000
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/1099-0801(200006)14:4<213::aid-bmc975>3.0.co;2-r
Subject(s) - desflurane , enflurane , chemistry , enantiomer , isoflurane , halothane , volatile anesthetic , inhalation , pharmacokinetics , chromatography , general anaesthetic , racemic mixture , pharmacodynamics , pharmacology , organic chemistry , anesthesia , general anaesthesia , medicine
This review discusses the various chromatographic enantioseparation methods on an analytical and preparative scale for fluorinated inhalation anaesthetics used clinically, namely halothane, enflurane, desflurane and isoflurane. The differences in the pharmacodynamics and pharmacokinetics between the enantiomers of those anaesthetics are presented. It can be concluded that using a single enantiomer for these fluorinated anaesthetics is advantageous over using the racemic mixture. The racemic switch to a single enantiomer for these fluorinated volatile anaesthetics offers a more effective and safe general anaesthetic. Copyright © 2000 John Wiley & Sons, Ltd.