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Synthesis, characterization and cytotoxic activity of complexes of diorganotin(IV) dihalides with mepirizole
Author(s) -
Álvarez Boo P.,
Casas J. S.,
Castellano E. E.,
Couce M. D.,
Freijanes E.,
Furlani A.,
Russo U.,
Scarcia V.,
Sordo J.,
Varela M.
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/1099-0739(200101)15:1<75::aid-aoc113>3.0.co;2-4
Subject(s) - chemistry , tin , denticity , octahedron , crystal structure , ligand (biochemistry) , stereochemistry , crystallography , chlorine , chlorine atom , mössbauer spectroscopy , atom (system on chip) , nuclear magnetic resonance spectroscopy , medicinal chemistry , proton nmr , organic chemistry , biochemistry , receptor , computer science , embedded system
Reaction of mepirizole (M) with diorganotin(IV) dihalides yielded compounds of type [SnR 2 X 2 (M)] (R, X = Et, Cl; Et, Br; Bu, Cl; Bu, Br; Ph, Cl). The structure of dichlorodiphenyl(mepirizole)tin(IV) was determined by X‐ray diffractometry. The crystal consists of discrete [SnPh 2 Cl 2 (M)] units in which an N , N ′‐bidentate mepirizole, the trans phenyl rings and the cis chlorine atoms define a pseudo‐octahedral coordination polyhedron around the tin atom. Mössbauer and vibrational spectroscopic data suggest similar structures for the other compounds prepared. The 1 H NMR spectra show that the mepirizole ligand is largely dissociated in CDCl 3 . The most active compounds against the human carcinoma cell line KB were the butyl derivatives.