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Toxicity and model membrane modifying properties of organolead compounds
Author(s) -
Sarapuk Janusz,
Bielecki Krzysztof,
Kleszczyńska Halina,
Dziamska Anna,
Przestalski Stanisław
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/1099-0739(200101)15:1<56::aid-aoc69>3.0.co;2-b
Subject(s) - chemistry , toxicity , membrane , environmental chemistry , organic chemistry , biochemistry
The influence of trialkylleads on haemolysis of red blood cells (RBCs), growth of Spirodela oligorrhiza and stability of planar lipid membranes (PLMs) at different pH of solution has been studied. The results obtained show that the efficiency of trialkylleads (methyl‐, ethyl‐, propyl‐ and butyl‐lead chlorides) in modifying the physiological and mechanical properties of the objects studied depended both on pH of solution and hydrophobicity of the compounds. Namely, it was found that this efficiency increased with pH of solution. The most significant increase was observed in PLM experiments. Also, the hydrophobicity of trialkylleads influenced the properties mentioned. The more hydrophobic a compound the greater was its haemolytic toxicity. The same applies to the physiological toxicity of the compounds, whose measure was 50% inhibition of plant growth. Generally, the sequence of modifying possibilities of the compounds studied at any pH of the solution was the following: tributyllead > tripropyllead > triethyllead > trimethyllead A possible mechanism of the interaction of organolead species with model and biological membranes is discussed. Copyright © 2001 John Wiley & Sons, Ltd.