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A New Approach to Phosphonate Analogues of Phosphatidyl Derivatives
Author(s) -
Brel Valery K.,
Stang Peter J.
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200301)2003:1<224::aid-ejoc224>3.0.co;2-3
Subject(s) - phosphonate , chemistry , moiety , stereochemistry , combinatorial chemistry , organic chemistry
A new method for the preparation of the phosphonate analogues of phosphatidyl derivatives using a Horner−Mark [2,3]‐sigmatropic rearrangement is described. Phosphonate analogues were prepared in which the sn ‐3 oxygen of the diacylglyceryl moiety is substituted by ‐HC=CH‐ or ‐CH 2 CH 2 ‐ fragments. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002)