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Domino Cyclization of 2‐Isothiocyanatobenzonitrile with Carboxylic Hydrazides − One‐Pot Synthesis of 1,2,4‐Triazolo[1,5‐ c ]quinazoline‐5(6 H )‐thiones
Author(s) -
Blank Janet,
Kandt Madeleine,
Pfeiffer WolfDiethard,
Hetzheim Annemarie,
Langer Peter
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200301)2003:1<182::aid-ejoc182>3.0.co;2-s
Subject(s) - chemistry , domino , quinazoline , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis
One‐pot reactions between carboxylic hydrazides and 2‐isothiocyanatobenzonitrile afforded pharmacologically relevant 1,2,4‐triazolo[1,5‐ c ]quinazoline‐5(6 H )‐thiones in good yields. These compounds were transformed into the corresponding amino‐substituted derivatives in good yields in one or two steps. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)