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Synthesis of Quinolinylphosphane Oxides and ‐phosphonates from N ‐Arylimines Derived from Phosphane Oxides and Phosphonates
Author(s) -
Palacios Francisco,
Aparicio Domitila,
Vicario Javier
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200212)2002:24<4131::aid-ejoc4131>3.0.co;2-w
Subject(s) - chemistry , aryl , dimethylformamide , medicinal chemistry , acetal , organic chemistry , combinatorial chemistry , solvent , alkyl
Quinolinylphosphane oxides are obtained by thermal treatment of N ‐arylimines derived from phosphane oxides with dimethylformamide diethyl acetal (DMF‐DEA). An intermediate N ‐aryl‐1‐azadiene was isolated and cyclization thereof leads to phosphorylated quinolines. In a similar manner, quinolinylphosphonates are obtained by reaction of N ‐arylimines derived from phosphonates with DMF‐DEA. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002)