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Trifluoromethyl‐Substituted Pyridines Through Displacement of Iodine by in situ Generated (Trifluoromethyl)copper
Author(s) -
Cottet Fabrice,
Schlosser Manfred
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(20021)2002:2<327::aid-ejoc327>3.0.co;2-v
Subject(s) - trifluoromethyl , chemistry , iodobenzene , copper , trifluoromethylation , pyridine , iodine , displacement (psychology) , iodide , organic chemistry , medicinal chemistry , catalysis , psychology , alkyl , psychotherapist
A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2‐Iodopyridines can be converted into 2‐(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3‐ and 4‐iodopyridines or 2‐bromopyridines are used as the starting materials.