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Efficient Synthesis of Nitrogen Heterocycles by Cyclization of Bis(nucleophiles) with Oxaldiimidoyl Dichlorides
Author(s) -
Langer Peter,
Döring Manfred
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(20021)2002:2<221::aid-ejoc221>3.0.co;2-m
Subject(s) - chemistry , nucleophile , domino , combinatorial chemistry , organic chemistry , catalysis
The reaction of ambident dianions and bis‐nucleophiles with oxaldiimidoyl dichlorides offers a new strategy for the regio‐ and diastereoselective synthesis of a variety of biologically relevant N‐heterocycles. This includes cyclization, domino, one‐pot, and double‐anion‐capture reactions.