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Studies on the Interactions of the New 2,6‐Bis[2‐(heteroaryl)vinyl]1‐methylpyridinium Cations with the Decamer d(CGTACGTACG) 2
Author(s) -
Fichera Maria,
Fortuna Cosimo G.,
Impallomeni Giuseppe,
Musumarra Giuseppe
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(20021)2002:1<145::aid-ejoc145>3.0.co;2-3
Subject(s) - chemistry , furan , pyrrole , nuclear magnetic resonance spectroscopy , intercalation (chemistry) , stereochemistry , medicinal chemistry , spectroscopy , organic chemistry , physics , quantum mechanics
The synthesis and spectroscopic characterization of 2,6‐bis[2‐(heteroaryl)vinyl]‐1‐methylpyridinium iodides (heteroaryl = 1‐methylpyrrol‐2‐yl, furan‐2‐yl, thiazol‐2‐yl, imidazol‐2‐yl, 5‐bromofuran‐2‐yl) is reported. Interactions of furan and pyrrole derivatives with the decamer duplex d(CGTACGTACG) 2 were clearly detectable by UV/Vis, CD, and 1 H NMR spectroscopy, and attention is drawn to the complementarity of the above techniques in such studies. The NMR evidence is consistent with literature data ascribed to intercalation.