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A New Multi‐Charged C 60 Derivative: Synthesis and Biological Properties
Author(s) -
Cusan Claudia,
Da Ros Tatiana,
Spalluto Giampiero,
Foley Sarah,
Janot JeanMarc,
Seta Patrick,
Larroque Christian,
Tomasini Maria Cristina,
Antonelli Tiziana,
Ferraro Luca,
Prato Maurizio
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200209)2002:17<2928::aid-ejoc2928>3.0.co;2-i
Subject(s) - chemistry , derivative (finance) , pyrrolidine , superoxide , xanthine oxidase , radical , xanthine , ethylene glycol , combinatorial chemistry , organic chemistry , enzyme , financial economics , economics
A new water‐soluble multi‐charged monoadduct fullero[60]pyrrolidine derivative with three ethylene glycol chains and three ammonium groups has been synthesized by means of two alternative synthetic pathways. Increasing the concentration of this C 60 derivative did not show a significant modification of concentration of superoxide anion radical O 2 · − , generated by the xanthine/xanthine oxidase system. Moreover, this C 60 derivative was ineffective for neuroprotection in quantitative assessment of a neuronal injury considered to occur via radicals. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)