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A Concise Synthesis of (+)‐Compactin Lactone by Asymmetric Dihydroxylation and Regioselective Cyclic Sulfite Opening Reactions
Author(s) -
Fernandes Rodney A.,
Kumar Pradeep
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200209)2002:17<2921::aid-ejoc2921>3.0.co;2-n
Subject(s) - chemistry , regioselectivity , dihydroxylation , enantioselective synthesis , lactone , sulfite , stereochemistry , nucleophile , organic chemistry , catalysis
A concise, enantioselective synthesis of compactin lactone 2 is described using the Sharpless asymmetric dihydroxylation and regioselective nucleophilic opening of cyclic sulfite as the key steps. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)