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Solvent‐Free Synthesis of Diaryl α‐Tetralones via Michael Addition under Microwave Irradiation
Author(s) -
Rissafi Bouchra,
El Louzi Ahmed,
Loupy André,
Petit Alain,
Soufiaoui Mohamed,
Fkih Tétouani Souâd
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200208)2002:15<2518::aid-ejoc2518>3.0.co;2-a
Subject(s) - chemistry , michael reaction , microwave irradiation , annulation , reagent , catalysis , tetralones , isophorone , microwave , solvent , organic chemistry , irradiation , photochemistry , physics , quantum mechanics , nuclear physics
A one‐pot synthesis of diaryldimethyl‐α‐tetralones via Michael addition and subsequent Robinson annulation reactions of isophorone with chalcones was carried out in solvent‐free conditions under microwave irradiation. The reagents were either supported on basic mineral solid supports or mixed with a phase‐transfer catalyst in basic medium. Substantial rate enhancements were observed and much shorter reaction times were needed upon microwave irradiation than by conventional heating. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)