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Synthesis and Resolution of BICOL, a Carbazole Analogue of BINOL
Author(s) -
Botman Peter N. M.,
Postma Martijn,
Fraanje Jan,
Goubitz Kees,
Schenk Henk,
Maarseveen Jan H. van,
Hiemstra Henk
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200206)2002:12<1952::aid-ejoc1952>3.0.co;2-l
Subject(s) - chemistry , carbazole , resolution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , computer science , artificial intelligence
The synthesis and resolution of a novel chiral C 2 ‐symmetric bicarbazolediol (BICOL), is reported. The key step in the synthesis is the copper(II)‐catalysed oxidative phenol coupling of 3‐hydroxycarbazole. Menthyl chloroformate is used as resolving agent for the separation of the two enantiomers of BICOL. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)