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A Study on the “Non‐Chelation Controlled” Organometallic Addition to trans α,β‐Epoxy Aldehydes − A Straightforward Stereoselective Synthesis of the Abbot Amino Dihydroxyethylene Dipeptide Isoster
Author(s) -
Righi Giuliana,
Ronconi Silvia,
Bonini Carlo
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200205)2002:9<1573::aid-ejoc1573>3.0.co;2-i
Subject(s) - chemistry , stereoselectivity , dipeptide , chelation , group 2 organometallic chemistry , diol , organic chemistry , epoxy , amino acid , catalysis , molecule , biochemistry
A study of the organometallic addition to α,β‐epoxy aldehydes in “non‐chelation controlled” conditions is reported. The conditions able to give the best stereoselectivities are used to prepare the Abbott amino diol. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)