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Amino‐Sulfonation of Alkenes in a Three‐Component Reaction
Author(s) -
Cordero Franca M.,
Cacciarini Martina,
Machetti Fabrizio,
De Sarlo Francesco
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200204)2002:8<1407::aid-ejoc1407>3.0.co;2-i
Subject(s) - chemistry , alkene , acetonitrile , amino acid , hydrolysis , organic chemistry , component (thermodynamics) , taurine , combinatorial chemistry , catalysis , biochemistry , physics , thermodynamics
2‐Aminoalkanesulfonic acids have been synthesized by a three‐component alkene/SO 3 ·DMF/acetonitrile reaction, followed by hydrolysis. Trifluoromethanesulfonic acid was added to the amino‐sulfonation mixture to accelerate the reaction and prevent the competitive formation of by‐products. The reported two‐step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)