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Solvent‐Free Microwave‐Assisted Aromatic Nucleophilic Substitution − Synthesis of Aromatic Ethers
Author(s) -
Chaouchi Mehdi,
Loupy André,
Marque Sylvain,
Petit Alain
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200204)2002:7<1278::aid-ejoc1278>3.0.co;2-b
Subject(s) - chemistry , nucleophilic aromatic substitution , nucleophilic substitution , radical nucleophilic aromatic substitution , solvent polarity , substitution reaction , nucleophile , leaving group , electrophilic aromatic substitution , nucleophilic addition , polarity (international relations) , microwave , solvent , organic chemistry , photochemistry , computational chemistry , catalysis , physics , quantum mechanics , biochemistry , cell
Specific (not purely thermal) microwave effects are shown to be highly dependent on the nature of the nucleophilic ion pairs and on the substituents and leaving groups on the aromatic substrates. This can be interpreted in terms of a polarity enhancement during the progress of the reaction and a shift of the position of the transition state along the reaction coordinates. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)