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Synthesis of Fluorescent Derivatives of the Antibiotic Moenomycin A
Author(s) -
Buchynskyy Andrij,
Kempin Uwe,
Vogel Stefan,
Hennig Lothar,
Findeisen Matthias,
Müller Dietrich,
Giesa Sabine,
Knoll Helmut,
Welzel Peter
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200204)2002:7<1149::aid-ejoc1149>3.0.co;2-h
Subject(s) - chemistry , fluorescence , antibiotics , combinatorial chemistry , organic chemistry , biochemistry , quantum mechanics , physics
Moenomycin has been highly selectively converted into amino derivative 3b . The primary amino group of this compound can be used to attach various fluorescent labels to moenomycin, through conversion of isothiocyanates into thioureas and squaric acid diesters into diamides. The application of some of the derivatives is outlined. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)