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Solid Phase Synthesis of Diamino‐Substituted Pyrimidines
Author(s) -
Barillari Caterina,
Barlocco Daniela,
Raveglia Luca F.
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200112)2001:24<4737::aid-ejoc4737>3.0.co;2-1
Subject(s) - chemistry , reactivity (psychology) , solid phase synthesis , nucleophilic aromatic substitution , combinatorial chemistry , nucleophilic substitution , nucleophile , phase (matter) , organic chemistry , stereochemistry , catalysis , biochemistry , medicine , peptide , alternative medicine , pathology
2,4‐ and 4,6‐Diamino‐substituted pyrimidines are known for their biological activity in many therapeutic areas. A novel solid‐phase synthesis of this class of compounds by nucleophilic aromatic substitution has been set up and the reactivity of differently substituted solid‐supported pyrimidines with properly selected amines has been studied. Using this methodology a small library of diamino‐substituted pyrimidines has been prepared.