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A Domino Spirocyclization to Form Lactams
Author(s) -
Tietze Lutz F.,
Steck Peter L.
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200111)2001:22<4353::aid-ejoc4353>3.0.co;2-b
Subject(s) - chemistry , domino , amide , cascade reaction , acrylic acid , michael reaction , combinatorial chemistry , organic chemistry , catalysis , polymer , monomer
Spirocyclic amides are easily obtained from primary amines, cycloenones and acrylic acid methyl ester. The key step is a two‐component domino process that includes the formation of an amide followed by a Michael addition in the presence of trimethylaluminum.