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Improvement of the Synthesis of Immunological Carbohydrate Vaccines Containing the Tumour Associate Antigen CaMBr1
Author(s) -
Lay Luigi,
Panza Luigi,
Poletti Laura,
Prosperi Davide,
Canevari Silvana,
Perico Maria Elisa
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200111)2001:22<4331::aid-ejoc4331>3.0.co;2-r
Subject(s) - chemistry , antigen , conjugated system , carbohydrate , immunology , biochemistry , biology , organic chemistry , polymer
The simplified synthesis of a portion of Globo‐H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.