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The Organometallic Approach to Molecular Diversity − Halogens as Helpers
Author(s) -
Schlosser Manfred
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200111)2001:21<3975::aid-ejoc3975>3.0.co;2-#
Subject(s) - chemistry , organometallic chemistry , halogen , diversity (politics) , group 2 organometallic chemistry , organic chemistry , stereochemistry , combinatorial chemistry , computational chemistry , molecule , catalysis , sociology , anthropology , alkyl
Strategies to functionalize simple, though structurally challenging, compounds in regiodivergent manner are outlined. The starting materials are inexpensive (5−500 €/mol) arenes or heterocycles bearing heterosubstituents such as Cl, F, CF 3 , OCF 3 , and OCH 3 . A metal is introduced at the targeted position either by direct hydrogen/metal exchange or, if this is not feasible, by use of organometallic precursor species as relay stations. The derivatives thus produced are versatile intermediates that may be employed as building blocks for further elaboration or even as scaffolds in combinatorial synthesis.