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Regioselective Alkylation Reactions of Enamines Derived from Phosphane Oxides − Synthesis of Phosphorus Substituted Enamino Esters, δ‐Amino‐phosphonates, Pyridone Derivatives and Pyrroles
Author(s) -
Palacios Francisco,
Aparicio Domitila,
García Jesús,
Vicario Javier,
Ezpeleta José María
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200109)2001:17<3357::aid-ejoc3357>3.0.co;2-j
Subject(s) - chemistry , regioselectivity , alkylation , substituent , alkyl , halide , amino esters , organic chemistry , medicinal chemistry , catalysis
α‐Substituted (2‐iminoalkyl)phosphane oxides were obtained from the azaenolates of imines or enamines and alkyl halides. The functionalized imines or enamines thus obtained were used for the synthesis of δ‐amino esters, δ‐amino phosphonates and heterocycles such as 3,4‐dihydropyridin‐2‐ones, 2‐pyridones and pyrroles containing a phosphinyl substituent.