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Synthesis and Hybridization Properties of Thiazolidine PNAs
Author(s) -
Bregant Sarah,
Burlina Fabienne,
Vaissermann Jacqueline,
Chassaing Gérard
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200109)2001:17<3285::aid-ejoc3285>3.0.co;2-v
Subject(s) - chemistry , thiazolidine , monomer , dna , peptide nucleic acid , nucleobase , combinatorial chemistry , rna , nucleic acid thermodynamics , stereochemistry , biochemistry , organic chemistry , base sequence , gene , polymer
Two new, constrained PNA monomers, each containing a thiazolidine ring, were synthesized and incorporated into a central position in a PNA. It was shown by UV melting experiments that the presence of a single constrained unit does not prevent the cooperative association of the PNA but does significantly destabilize PNA/DNA and PNA/RNA triplexes.