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A Rational Approach to Heparin‐Related Fragments − Synthesis of Differently Sulfated Tetrasaccharides as Potential Ligands for Fibroblast Growth Factors
Author(s) -
Poletti Laura,
Fleischer Martin,
Vogel Christian,
Guerrini Marco,
Torri Giangiacomo,
Lay Luigi
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200107)2001:14<2727::aid-ejoc2727>3.0.co;2-8
Subject(s) - chemistry , disaccharide , sulfation , iduronic acid , fibroblast growth factor , heparin , glucosamine , stereochemistry , sequence (biology) , glycosaminoglycan , biochemistry , heparan sulfate , receptor
Heparin‐like tetrasaccharides 1−3 , differing in their sulfation pattern at position 6 of the glucosamine units, were synthesised. The three compounds are putative ligands for fibroblast growth factors and have the unusual sequence (GlcN‐IdoA). They were obtained from two common disaccharide precursors by a versatile synthetic procedure.