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A New Stereoselective Synthesis of (±)‐Grandisol Based on the Remote Alkylation Protocol
Author(s) -
Monteiro Hugo J.,
Stefani Helio A.
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200107)2001:14<2659::aid-ejoc2659>3.0.co;2-x
Subject(s) - stereoselectivity , chemistry , alkylation , derivative (finance) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , financial economics , economics
A new stereoselective synthesis of (±)‐grandisol ( 1a ) has been developed. The synthesis starts with a simple cyclobutyl derivative to which the methyl group and the 1,2‐ cis disposed side chains were appended through a remote alkylation protocol.