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A New Convenient Synthesis of 3‐Carboxycephems Starting from 7‐Aminocephalosporanic Acid (7‐ACA)
Author(s) -
Keltjens Rolf,
Vadivel Subramanian K.,
de Vroom Erik,
Klunder Antonius J. H.,
Zwanenburg Binne
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200107)2001:13<2529::aid-ejoc2529>3.0.co;2-9
Subject(s) - chemistry , yield (engineering) , ring (chemistry) , cephem , sulfur , combinatorial chemistry , oxidation state , double bond , stereochemistry , organic chemistry , carboxylic acid , catalysis , materials science , metallurgy
New convenient syntheses of 3‐carboxycephems starting from 7‐ACA are reported. All three possible cephem derivatives with respect to the position of the double bond in the six‐membered ring and oxidation state of the sulfur atom have been synthesized in high overall yield.