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Synthesis and Absolute Configuration of (−)‐Neuchromenin, a Neurotrophic Metabolite of Eupenicillium javanicum var. meloforme , and Its Enantiomer
Author(s) -
Tanada Yoshihisa,
Mori Kenji
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200105)2001:10<1963::aid-ejoc1963>3.0.co;2-k
Subject(s) - chemistry , enantiomer , metabolite , absolute configuration , stereochemistry , benzopyran , biochemistry
Both the enantiomers of neuchromenin 1 (2,3‐dihydro‐8,9‐dihydroxy‐2‐methyl‐4 H ,5 H ‐pyrano[3,2‐ c ][1]benzopyran‐4‐one) were synthesized starting from the enantiomers of ethyl 3‐hydoxybutanoate ( 7 ). The naturally occurring (−)‐neuchromenin, a neurotrophic metabolite of Eupenicillium javanicum var. meloforme , was shown to be ( S )‐ 1 .