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Trifluoromethylation of Nonenolizable Carbonyl Compounds with a Stable Piperazino Hemiaminal of Trifluoroacetaldehyde
Author(s) -
Billard Thierry,
Langlois Bernard R.,
Blond Gaëlle
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200104)2001:8<1467::aid-ejoc1467>3.0.co;2-a
Subject(s) - hemiaminal , chemistry , reagent , trifluoromethylation , organic chemistry , nucleophile , catalysis , alkyl , trifluoromethyl
A new stable hemiaminal of fluoral ( 1 ) can easily be obtained from the methyl hemiketal of fluoral and N ‐benzylpiperazine. This white crystalline compound can be used under basic conditions as an efficient nucleophilic trifluoromethylating reagent towards nonenolizable carbonyl compounds.