Premium
Resolution of Racemic Acids by Irreversible Lipase‐Catalyzed Esterification in Organic Solvents
Author(s) -
Morrone Raffaele,
Piattelli Mario,
Nicolosi Giovanni
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200104)2001:8<1441::aid-ejoc1441>3.0.co;2-d
Subject(s) - chemistry , kinetic resolution , lipase , catalysis , organic chemistry , resolution (logic) , biocatalysis , combinatorial chemistry , enantioselective synthesis , enzyme , reaction mechanism , artificial intelligence , computer science
The reversible nature of the direct esterification of acids with alcohols limits the use of this process in the biocatalytic kinetic resolution of chiral acids. A new irreversible procedure, using orthoesters, has been developed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom