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Resolution of Racemic Acids by Irreversible Lipase‐Catalyzed Esterification in Organic Solvents
Author(s) -
Morrone Raffaele,
Piattelli Mario,
Nicolosi Giovanni
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200104)2001:8<1441::aid-ejoc1441>3.0.co;2-d
Subject(s) - chemistry , kinetic resolution , lipase , catalysis , organic chemistry , resolution (logic) , biocatalysis , combinatorial chemistry , enantioselective synthesis , enzyme , reaction mechanism , artificial intelligence , computer science
Abstract The reversible nature of the direct esterification of acids with alcohols limits the use of this process in the biocatalytic kinetic resolution of chiral acids. A new irreversible procedure, using orthoesters, has been developed.