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Synthesis of New Phosphonated Tripod Ligands as Putative New Therapeutic Agents in the Chelation Treatment of Metal Intoxications
Author(s) -
Burgada Ramon,
Bailly Theodorine,
Lecouvey Marc,
Larue Valery,
Leroux Yves
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200101)2001:2<349::aid-ejoc349>3.0.co;2-f
Subject(s) - tripod (photography) , chemistry , chelation , phosphonate , chelation therapy , combinatorial chemistry , metal , stereochemistry , organic chemistry , physics , optics
In a quest for new chelation therapy drugs for the treatment of intoxication by actinides, some new phosphonated chelating tripod ligands have been synthesized. They have been obtained by means of a coupling reaction between a diethylphosphonoalkanoic acid activated with N , N′ ‐disuccinimidyl carbonate (DSC) and a series of polyamines, with subsequent deprotection of the phosphonate groups.