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Synthesis of Benzo[ b ]phenanthridines and Related Naturally Occurring 2‐Aryl‐1,4‐naphthoquinones by Palladium‐ and Copper‐Catalyzed Coupling of Organostannanes with Bromoquinones
Author(s) -
Frutos Óscar de,
Atienza Carmen,
Echavarren Antonio M.
Publication year - 2001
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200101)2001:1<163::aid-ejoc163>3.0.co;2-3
Subject(s) - chemistry , palladium , aryl , steric effects , copper , catalysis , suzuki reaction , combinatorial chemistry , organic chemistry , coupling (piping) , medicinal chemistry , mechanical engineering , alkyl , engineering
Syntheses of phenanthroviridone, gilvocarcin BE‐12406X 2 , antibiotic WS 5995B, and a key intermediate for the synthesis of jadomycin are described, based on palladium‐ and copper‐catalyzed coupling reactions of sterically hindered arylstannanes with 2‐bromonaphthoquinones.