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Synthesis and Functionalization of New Tropanes Designed for Use as Scaffolds in Combinatorial Chemistry
Author(s) -
Paparin JeanLaurent,
Crévisy Christophe,
Toupet Loïc,
Grée René
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200012)2000:23<3909::aid-ejoc3909>3.0.co;2-r
Subject(s) - chemistry , surface modification , diethylzinc , cycloaddition , combinatorial chemistry , organic chemistry , catalysis , enantioselective synthesis
The [4+3] cycloaddition reaction between alkyloxycarbonyl‐substituted pyrroles and α,α′‐dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.