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A Straightforward Synthesis of Cyclopropanes from Aldehydes and Ketones
Author(s) -
Gandon Vincent,
Bertus Philippe,
Szymoniak Jan
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200011)2000:22<3713::aid-ejoc3713>3.0.co;2-1
Subject(s) - chemistry , ketone , organic chemistry , cyclopropanation , aldehyde , combinatorial chemistry , computational chemistry , catalysis
A new synthetic methodology for preparing cyclopropanes is presented. The reaction involves a cooperative zirconium‐ and Lewis acid‐mediated deoxygenative coupling of carbonyl compounds with a Grignard reagent. In this way, various cyclopropanes are obtained in moderate to excellent yields, directly from saturated, unsaturated, and aromatic aldehydes and ketones. This reaction tolerates the presence of several different functional groups.