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Synthesis and Antifungal Activity of the Four Stereoisomers of Streptimidone, a Glutarimide Antibiotic from Streptomyces rimosus forma paromomycinus
Author(s) -
Kondo Hitoshi,
Oritani Takayuki,
Kiyota Hiromasa
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200010)2000:20<3459::aid-ejoc3459>3.0.co;2-f
Subject(s) - chemistry , diastereomer , antifungal , stereochemistry , antimicrobial , antibiotics , streptomyces , streptomycetaceae , actinomycetales , microbiology and biotechnology , organic chemistry , bacteria , biochemistry , biology , genetics
Four stereoisomers of streptimidone (1) , an antibiotic from Streptomyces rimosus forma paromomycinus , were synthesized from methyl ( S )‐3‐hydroxy‐2‐methylpropanoate. The natural diastereomer 1 shows the strongest antimicrobial activity.