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Dialkyl 1‐Alkynylphosphonates: a Range of Promising Reagents
Author(s) -
Iorga Bogdan,
Eymery Frédéric,
Carmichael Duncan,
Savignac Philippe
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200009)2000:18<3103::aid-ejoc3103>3.0.co;2-v
Subject(s) - nucleophile , reactivity (psychology) , cycloaddition , reagent , combinatorial chemistry , chemistry , phosphorus , organic chemistry , catalysis , medicine , alternative medicine , pathology
This review covers the preparations of 1‐alkynylphosphonates by Michaelis–Arbuzov and Michaelis–Becker reactions, by nucleophilic substitutions at phosphorus (SNP V ), and by elimination from 1‐alkenylphosphonates. The reactivity and versatility of 1‐alkynylphosphonates have made them valuable precursors for other phosphonates, and particularly for the synthesis of heterocycles by [2+2], [3+2], and [4+2] cycloaddition reactions.