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A New Strategy for the Stereoselective Synthesis of 1,2,3‐Trisubstituted Cyclopropanes
Author(s) -
Böhm Claudius,
Schinnerl Marina,
Bubert Christian,
Zabel Manfred,
Labahn Thomas,
Parisini Emilio,
Reiser Oliver
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200008)2000:16<2955::aid-ejoc2955>3.0.co;2-3
Subject(s) - chemistry , stereoselectivity , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
The stereoselective synthesis of highly functionalized 1,2,3‐trisubstituted cyclopropanes 1 and 2 , starting from readily available furans 3 or N ‐protected pyrrole 4 , is described. Furthermore, exceptionally high diastereocontrol in agreement with the Felkin−Anh model was observed for the addition of nucleophiles to the title compounds.