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Synthesis of P , P′ ‐Heterotopic Binaphthyldiphosphanes (BINAPP′) Devoid of C 2 Symmetry from 2,2′‐Binaphthol
Author(s) -
Gladiali Serafino,
Dore Antonio,
Fabbri Davide,
Medici Serenella,
Pirri Giovanna,
Pulacchini Sonia
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200008)2000:16<2861::aid-ejoc2861>3.0.co;2-v
Subject(s) - chemistry , trifluoromethanesulfonate , substituent , catalysis , medicinal chemistry , palladium , allylic rearrangement , alkylation , combinatorial chemistry , stereochemistry , organic chemistry
The introduction of two nonequivalent diarylphosphanyl substituents into the 2‐ and 2′‐positions of 1,1′‐binaphthalene has been successfully accomplished in four steps from 1,1′‐binaphthalene‐2,2′‐diol (BINOL) through conversion into the ditriflate followed by sequential substitution of triflate groups mediated by palladium or nickel catalysts. The selective monosubstitution of the triflate has been achieved by introducing the first phosphorated substituent in the form of phosphane oxide through a Pd‐catalyzed reaction. The o ‐tolyl‐substituted diphosphane 4c is a chiral inducer that is more efficient than BINAP both in the Rh‐catalyzed asymmetric hydrogenation of acetamido acrylic acid derivatives and in the Pd‐catalyzed allylic alkylation of 1,3‐diphenylprop‐2‐enyl acetate (85% ee ).