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Convergent Synthesis of 1α‐Hydroxyvitamin D 5
Author(s) -
Gao LingJie,
Zhao XuYang,
Vandewalle Maurits,
Clercq Pierre De
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200008)2000:15<2755::aid-ejoc2755>3.0.co;2-g
Subject(s) - chemistry , side chain , sequence (biology) , vitamin d and neurology , convergent synthesis , stereochemistry , organic chemistry , biochemistry , medicine , polymer , endocrinology
An eleven‐step, high‐yielding (46%) synthesis of 1α‐hydroxyvitamin D 5 ( 2 ) starting from vitamin D 2 ( 4 ) is described, in which a Julia olefination sequence is used for the construction of the (24 R )‐ethyl‐substituted side chain.