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Synthesis of 4,5,12,13‐Tetraformyl[2.2]paracyclophane and Its Bis‐acetal
Author(s) -
Sankararaman Sethuraman,
Hopf Henning,
Dix Ina,
Jones Peter G.
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200008)2000:15<2699::aid-ejoc2699>3.0.co;2-r
Subject(s) - acetal , chemistry , cycloaddition , hydrolysis , crystal structure , medicinal chemistry , stereochemistry , organic chemistry , catalysis
4,5,12,13‐Tetraformyl[2.2]paracyclophane ( 1f ) has been prepared for the first time by the cycloaddition of 4,4‐diethoxy‐2‐butynal ( 3 ) to 1,2,4,5‐hexatetraene ( 2 ) under various conditions and hydrolysis of the initially produced bis‐acetals 5a and 5b . An X‐ray crystal structural analysis of 5a is reported.