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Asymmetric Synthesis of ( S )‐β 2 ‐Homoarylglycines
Author(s) -
Calmès Monique,
Escale Françoise,
Glot Christèle,
Rolland Marc,
Martinez Jean
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200007)2000:13<2459::aid-ejoc2459>3.0.co;2-d
Subject(s) - chemistry , enantioselective synthesis , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
The synthesis of racemic N ‐phthalyl β 2 ‐homoarylglycines 5 and their asymmetric transformation have been investigated. The key step is the stereoselective addition of the ( R )‐pantolactone to the corresponding prochiral ketene 7 .