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Asymmetric Synthesis of 1,4‐Disubstituted Tetrahydroioquinolines
Author(s) -
Jullian Valerie,
Quirion JeanCharles,
Husson HenriPhilippe
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200004)2000:7<1319::aid-ejoc1319>3.0.co;2-j
Subject(s) - chemistry , enantioselective synthesis , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
Bischler‐Napieralski cyclisation of optically active β‐substituted phenylethylamines 4a‐c followed by diastereoselective reduction led to 1,4‐disubstituted tetrahydroisoquinolines 6a‐c and 8a‐c . The same methodology afforded the 4‐benzyl pyrroloisoquinolines 10 .