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Synthesis of Diospyrin, a Potential Agent Against Leishmaniasis and Related Parasitic Protozoan Diseases
Author(s) -
Yoshida Masao,
Mori Kenji
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200004)2000:7<1313::aid-ejoc1313>3.0.co;2-i
Subject(s) - chemistry , protozoan parasite , leishmaniasis , naphthoquinone , leishmania , suzuki reaction , stereochemistry , key (lock) , combinatorial chemistry , protozoa , parasite hosting , organic chemistry , microbiology and biotechnology , immunology , world wide web , computer science , biology , ecology , alkyl , aryl
The first synthesis of diospyrin [2,6′‐bis(5‐hydroxy‐7‐methyl‐1,4‐naphthoquinone), 1 ] was achieved by employing Suzuki coupling between 5 and 14 as the key reaction to connect the two 7‐methyljuglone units.