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Carboxylation of 2‐Hydroxyethyl‐Substituted Tetrachloro(ethane‐1,2‐diamine)platinum(IV) Complexes — A New Synthetic Approach to Anticancer Platinum Compounds
Author(s) -
Galanski Mathea Sophia,
Zimmermann Wolfgang,
Berger Michael,
Baumgartner Christian,
Giester Gerald,
Keppler Bernhard Klaus
Publication year - 2002
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(20022)2002:2<417::aid-ejic417>3.0.co;2-4
Subject(s) - chemistry , platinum , diamine , moiety , oxidizing agent , combinatorial chemistry , molecule , electrophile , organic chemistry , polymer chemistry , catalysis
The present study has focused on a general reaction procedure for the derivatization of hydroxyethyl‐substituted tetrachloro(ethane‐1,2‐diamine)platinum(IV) compounds at peripheral hydroxyl groups using acyl chlorides. A new class of platinum(IV) complexes could be synthesized which now opens the possibility for the first time to couple the cytotoxic platinum(IV) moiety to carrier molecules like proteins and antibodies in a very selective way. Moreover, it is now possible to synthesize platinum(IV) complexes with ligands in the equatorial plane which are not very stable in the presence of oxidizing agents.