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Structure, Properties and Cytostatic Activity of Triorganotin (Aminoaryl)carboxylates
Author(s) -
Pruchnik Florian P.,
Bańbuła Małgorzata,
Ciunik Zbigniew,
Chojnacki Henryk,
Latocha Małgorzata,
Skop Barbara,
Wilczok Tadeusz,
Opolski Adam,
Wietrzyk Joanna,
Nasulewicz Anna
Publication year - 2002
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200212)2002:12<3214::aid-ejic3214>3.0.co;2-k
Subject(s) - chemistry , crystallography , crystal structure , oxygen atom , trigonal bipyramidal molecular geometry , ligand (biochemistry) , hydrogen bond , atom (system on chip) , stereochemistry , nitrogen atom , carboxylate , nitrogen , group (periodic table) , molecule , receptor , organic chemistry , biochemistry , computer science , embedded system
The properties of vinyltin and phenyltin complexes [Sn(CH=CH 2 ) 3 {μ‐OOCC 6 H 3 (NH 2 ) 2 ‐3,4}] n ( 1 ), [Sn(C 6 H 5 ) 3 {OOCC 6 H 3 (NH 2 ) 2 ‐3,4}] ( 2 ), [Sn(C 6 H 5 ) 3 {OOC‐2‐C 6 H 4 N=NC 6 H 4 N(CH 3 ) 2 ‐4}] ( 3 ) and [Sn(CH=CH 2 ) 3 {OOC‐2‐C 6 H 4 N=NC 6 H 4 N(CH 3 ) 2 ‐4}] ( 4 ) have been investigated. The structures of complexes 1 , 2 , and 3 , have been determined by X‐ray crystallography. Compound 1 is a distorted trigonal‐bipyramidal complex and compounds 2 and 3 adopt a distorted tetrahedral structure. Complex 1 is a single‐strand polymer with a bridging 3,4‐diaminobenzoato ligand coordinating via the O(1) atom of the carboxylato group and the nitrogen atom of the para ‐amino group. The oxygen and nitrogen atoms occupy the axial coordination sites. The Sn(1)−N(2A) bond is weak. In complexes 2 and 3 the carboxylato ligands are strongly coordinated to the central atom via one oxygen atom, and the Sn(1)−O(2) distances are considerably longer. Weak interactions of the central atom with the amino group in complex 1 , and with the O(2) atoms in complexes 2 and 3 , as well as the hydrogen bonds, stabilize the crystal structure. The complexes are effective cytostatic agents. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)