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Regio‐Directed Synthesis of a Zn II Fe III Complex from an Unsymmetrical Ligand and Its Relevance to Purple Acid Phosphatases
Author(s) -
Belle Catherine,
GautierLuneau Isabelle,
Karmazin Lydia,
Pierre JeanLouis,
Albedyhl Sabine,
Krebs Bernt,
Bonin Michel
Publication year - 2002
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200212)2002:12<3087::aid-ejic3087>3.0.co;2-0
Subject(s) - chemistry , coordination sphere , ligand (biochemistry) , regioselectivity , crystal structure , stereochemistry , zinc , oxygen atom , phosphatase , amino acid , coordination complex , medicinal chemistry , crystallography , metal , molecule , enzyme , receptor , catalysis , organic chemistry , biochemistry
A new heterodinuclear Zn II Fe III μ‐phenoxy complex has been prepared and isolated from the unsymmetrical ligand 2{[bis(2‐hydroxybenzyl)]amino}methyl‐6‐{[2‐pyridinylmethyl)amino]methyl}‐4‐methylphenol (H 3 L 1 ), which provides two distinct N‐ and O‐rich donor sets. The regioselective complexation is confirmed in solution by 1 H NMR studies (comparison of the spectra obtained from H 3 L 1 and HL 2 − a ligand with only the N‐donor set available − and a zinc salt). The crystal structure of the bis(μ‐diphenylphosphato)Zn II Fe III complex [ZnFeL 1 {O 2 P(OPh) 2 } 2 ] ( 1 ) is reported. The NO 5 coordination sphere around the Fe III reproduces, for the first time, the oxygen‐rich coordination sphere around iron( III ) in red kidney bean purple acid phosphatase (KBPAP). (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)