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Novel Ru III ‐DMSO Complexes of the Antiherpes Drug Acyclovir
Author(s) -
Turel Iztok,
Pečanac Milena,
Golobič Amalija,
Alessio Enzo,
Serli Barbara
Publication year - 2002
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200208)2002:8<1928::aid-ejic1928>3.0.co;2-a
Subject(s) - chemistry , protonation , methanol , hydrogen bond , medicinal chemistry , combinatorial chemistry , oxygen atom , stereochemistry , organic chemistry , molecule , ion
Treatment of the anionic Ru III precursor X[ trans ‐RuCl 4 (DMSO‐ S ) 2 ] (X = protonated DMSO, Na + , NH 4 + ) and acyclovir (acv) in various solvents yields two new products mer ‐[RuCl 3 (acv)(DMSO‐ S )(CH 3 OH)]·0.5CH 3 OH ( 1 ) and mer ‐[RuCl 3 (acv)(DMSO‐ S )(H 2 O)]·H 2 O ( 2 ) in which hydrogen bonds between the acv purine oxygen and coordinated methanol or water, respectively, play an important role. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)