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Synthesis and Structural Characterization of (Carbene)ruthenium Complexes Binding Nucleobases
Author(s) -
Fillaut JeanLuc,
de los Rios Isaac,
Masi Dante,
Romerosa Antonio,
Zanobini Fabrizio,
Peruzzini Maurizio
Publication year - 2002
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200203)2002:4<935::aid-ejic935>3.0.co;2-i
Subject(s) - ruthenium , chemistry , nucleobase , carbene , metallacycle , uracil , stereochemistry , crystal structure , derivative (finance) , medicinal chemistry , x ray crystallography , dna , crystallography , catalysis , organic chemistry , biochemistry , physics , diffraction , financial economics , optics , economics
The new (carbene)ruthenium(II) nucleobase derivatives fac , cis ‐[(PNP)RuCl{C(NHC 4 H 3 N 2 O 2 )(CH 2 Ph)}]Cl ( 5 ) and fac , cis ‐[(PNP)RuCl{C(NHC 5 H 3 N 4 )(CH 2 Ph)}]Cl ( 6 ) [PNP = CH 3 CH 2 CH 2 N(CH 2 CH 2 PPh 2 ) 2 ] were synthesised by treating (vinylidene)ruthenium(II) complex fac , cis ‐[(PNP)RuCl 2 {C=C(H)Ph}] ( 1 ) with 5‐aminouracil or adenine, respectively. Both complexes were characterized by spectroscopic techniques (IR and NMR) and elemental analyses, which confirmed the formation of the aminocarbene moieties incorporating 1 equiv. of the nucleobase in the complex framework. Crystal and molecular structure determination by X‐ray diffraction analysis of the uracil derivative 5 revealed a very unusual O ‐coordination of the exocyclic C=O group on the C(4) atom of the uracil ring to the ruthenium atom leading to an unprecedented six‐membered aminocarbene metallacycle. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)